Drug intelligence / Profile preview

Lu AF28996

Development stage
Phase 2
Lead developer
Lundbeck
Modality
Small Molecules
Administration
Oral
01

Overview

Lu AF28996 is an orally administered small molecule drug under development by Lundbeck for the treatment of Parkinson's disease. It acts as a potent, long-acting dopamine D1 receptor and dopamine D2 receptor agonist, aiming to restore dopaminergic signaling in the brain to improve motor symptoms associated with Parkinson's disease. The compound is currently in phase 1 clinical trials evaluating its safety, tolerability, pharmacokinetics, and pharmacodynamics in both healthy volunteers and patients with Parkinson's disease[1][2][5]. Lu AF28996 is considered a new molecular entity and has not been granted orphan drug status[1].

02

Targets

DRD1 (Dopamine D1 Receptor)DRD2 (Dopamine D2 Receptor)

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