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Lu AF95245
- Development stage
- Unknown
- Lead developer
- Lundbeck
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Lu AF95245 is a small molecule drug developed by H. Lundbeck for the treatment of central nervous system disorders. It acts as an agonist of potassium channels, specifically activating the Kv7.2–Kv7.5 (KCNQ2-5) subtypes, which are important in regulating neuronal excitability. The drug was investigated primarily for its potential use in neurological or psychiatric conditions but did not progress beyond early clinical development due to an unfavorable pharmacokinetic profile. Clinical trials included phase 1 studies assessing safety and tolerability in healthy volunteers. Development has since been discontinued.
02
Targets
KCNQ3 (Potassium voltage-gated channel subfamily Q member 3)KCNQ4 (Potassium channel subfamily KQT member 4)KCNQ2 (Potassium voltage-gated channel subfamily KQT member 2)KCNQ5 (Potassium voltage-gated channel subfamily KQT member 5)
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