Drug intelligence / Profile preview

lubabegron

Development stage
Unknown
Lead developer
Elanco
Modality
Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Lubabegron, marketed under the brand name Experior, is a veterinary pharmaceutical drug approved for use in beef cattle. It is the first FDA-approved product specifically labeled to reduce ammonia gas emissions from an animal or its waste. Lubabegron acts as a beta-adrenergic receptor agonist/antagonist (β-AAA), with antagonist activity at β1 and β2 receptors and agonist activity at β3 receptors. This unique mechanism allows it to reduce ammonia emissions without causing the negative side effects associated with other beta-agonists that stimulate β1 and β2 receptors. The drug is administered to beef steers and heifers fed in confinement for slaughter during their final 14 to 91 days on feed. Its primary benefit is environmental stewardship by reducing ammonia gas released from manure, which can contribute to atmospheric haze, noxious odors, and eutrophication of water bodies[3][7][8].

Brand names
Experior
02

Targets

ADRB3 (β3)ADRB2 (β2)ADRB1 (β1)

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