Lubion (progesterone)

Lubion is a brand name for a specific aqueous solution of progesterone (25 mg) designed for subcutaneous injection, primarily used for luteal phase support in women undergoing assisted reproductive technology (ART). Developed by IBSA Institut Biochimique SA, the formulation utilizes hydroxypropyl-β-cyclodextrin (HPBCD) to enhance the solubility of the lipophilic progesterone molecule in water. This innovation allows for subcutaneous self-administration, providing a more patient-friendly alternative to traditional oil-based intramuscular progesterone injections, which are often associated with injection site pain, sterile abscesses, and the requirement for professional administration. Progesterone is a naturally occurring steroid hormone that binds to the progesterone receptor, inducing the secretory transformation of the endometrium to facilitate embryo implantation and support the maintenance of early pregnancy.

Brand names

LubionProlutex

Other names

progesterone injection