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Lubriderm is a brand of over-the-counter (OTC) emollient moisturizers designed to hydrate and protect the skin barrier. Originally developed for dermatological use, the product line typically contains a combination of humectants, such as glycerin, and occlusive agents, such as mineral oil and dimethicone. These ingredients work to restore the stratum corneum's moisture levels and prevent transepidermal water loss. In clinical research, Lubriderm is frequently employed as an inert vehicle or placebo control in studies involving topical applications, such as capsaicin-induced central sensitization models, due to its non-sensitizing and neutral properties. The brand was historically developed by Warner-Lambert and Pfizer before being acquired by Johnson & Johnson, and it is currently marketed by Kenvue.
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