Drug intelligence / Profile preview

LucyTx-1209

Development stage
Preclinical
Lead developer
Lucy Therapeutics
Modality
Small Molecules
Administration
Unknown
01

Overview

LucyTx-1209 is a preclinical, proprietary small molecule drug candidate developed by Lucy Therapeutics. Designed to target mitochondrial dysfunction, it acts by selectively inhibiting the F1F0-ATPase complex (part of the mitochondrial electron transport chain) to reverse mitochondrial deficits implicated in neurodegenerative diseases, notably Parkinson’s disease. In preclinical studies, LucyTx-1209 has shown potential to restore neuronal health by improving mitochondrial function, enhancing cellular ATP production, rescuing neurons, and reducing pathogenic alpha-synuclein accumulation. The compound is also part of broader research efforts at Lucy Therapeutics for diseases such as Alzheimer's disease and Rett syndrome[1][2][3][4][7][9].

Other names
LucyTx-1209LucyTx1209LucyTx 1209
02

Targets

ATP Synthase

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