Drug intelligence / Profile preview

Lufenuron

Development stage
Unknown
Lead developer
Novartis
Modality
Small Molecules
Administration
Oral, Subcutaneous
01

Overview

Lufenuron is a benzoylurea insecticide and insect growth regulator (IGR) primarily used in veterinary medicine for the control of flea infestations in animals such as dogs, cats, rabbits, and ferrets. It functions by inhibiting chitin synthesis, a critical process for the formation of the insect exoskeleton. This mechanism prevents the proper development and hatching of insect larvae and eggs, effectively interrupting the flea life cycle without directly killing adult fleas. Beyond its veterinary applications, Lufenuron is also utilized as an agricultural pesticide against various insects, including lepidopterans, eriophyid mites, and western flower thrips. Additionally, it has been explored for its antifungal properties, as fungal cell walls also contain chitin.

Brand names
ProgramZatox 50 ECZatox50 ECZatox-50 ECMatch 50 ECMatch50 ECMatch-50 ECLibertadFerfenuronProgram 40mg Suspension for InjectionProgram40mg Suspension for InjectionProgram-40mg Suspension for InjectionProgram Tablets 204.9 mg
02

Targets

CYP81A12 (Cytochrome P450 81A12)Chitin Synthase (Insect)CYP81A21 (Cytochrome P450 81A21)

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