Drug intelligence / Profile preview

Lulinol

Development stage
Unknown
Lead developer
Galcare Pharmaceutical
Modality
Small Molecules
Administration
Topical
01

Overview

Lulinol is a topical antifungal medication containing luliconazole (1% w/v), an imidazole derivative. Developed and marketed by Galcare Pharmaceutical, it is primarily used for the treatment of dermatological fungal infections such as tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm). Lulinol works by inhibiting the enzyme lanosterol 14-alpha demethylase, which is responsible for converting lanosterol to ergosterol. The resulting depletion of ergosterol and accumulation of methylated precursors lead to the disruption of the fungal cell membrane structure and function, ultimately exerting a fungicidal effect against dermatophytes like *Trichophyton rubrum* and *Epidermophyton floccosum*.

Brand names
Lulinol
Other names
luliconazole
02

Targets

CYP51A1 (Sterol 14α-demethylase)

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