Drug intelligence / Profile preview

lumbricus rubellus extract + fluocinolone acetonide

Development stage
Preclinical
Lead developer
Dexa Medica
Modality
Small Molecules
Administration
Topical, Oral
01

Overview

A combination of Lumbricus rubellus extract (earthworm extract) and fluocinolone acetonide (a synthetic corticosteroid). Lumbricus rubellus extract contains bioactive compounds including fibrinolytic enzymes, polyphenols, and G-90 glycoproteins with antioxidant, anti-inflammatory, antibacterial, and immunomodulatory properties. The extract has been shown to reduce oxidative stress markers (malondialdehyde and 8-hydroxy-deoxyguanosine), decrease amino transaminase enzyme levels (ALT and AST), and exhibit antibacterial activity against various pathogens such as Porphyromonas gingivalis and Salmonella typhimurium. It also has hepatoprotective, anti-pyretic, anti-apoptosis, anti-thrombosis, anti-coagulation, anti-ischemia, tissue regeneration, and wound healing properties. Fluocinolone acetonide is a synthetic corticosteroid with potent anti-inflammatory properties.

02

Targets

GR (Glucocorticoid receptor)

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