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Lumen malaria VLP vaccine
- Development stage
- Preclinical
- Lead developer
- Lumen Bioscience
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intranasal, Oral
01
Overview
Lumen malaria VLP vaccine is an investigational, needle-free, and cold-chain independent recombinant vaccine developed by Lumen Bioscience in collaboration with the University of Washington for the prevention of malaria. The vaccine consists of virus-like particles (VLPs) assembled from recombinant hepatitis B capsid antigen displaying the NANP repeat of the *Plasmodium falciparum* circumsporozoite protein (PfCSP). It is produced using Lumen's proprietary spirulina-based biomanufacturing platform, allowing for low-cost, scalable production. Designed for mucosal delivery, the vaccine can be administered orally or intranasally to elicit systemic IgG responses and is being developed as a seasonal booster to sustain malaria immunity.
- Other names
- Lumen's malaria vaccineLumen's unadjuvanted malaria vaccinespirulina PfCSP vaccinespirulina malaria vaccine
02
Targets
CSP (Circumsporozoite protein)
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