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lumicitabine
- Development stage
- Discontinued
- Lead developer
- Janssen Research & Development
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Lumicitabine (ALS-8176) is an orally bioavailable nucleoside analog prodrug designed for the treatment of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) infections. Developed by Alios BioPharma and later acquired by Janssen, the drug is metabolized into its active triphosphate form, which acts as a potent inhibitor of the viral RNA-dependent RNA polymerase (RdRp). By mimicking natural nucleosides, it incorporates into the nascent viral RNA chain, leading to premature chain termination and a significant reduction in viral load. Clinical development reached Phase 2 for both RSV in infants and adults, as well as hMPV, but Janssen discontinued the program in late 2020 following a strategic portfolio review.
- Other names
- 2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-diisobutyrate
02
Targets
RSV L (Respiratory syncytial virus L protein)
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