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Luminal type-2
- Development stage
- Phase 2
- Lead developer
- The Second Hospital of Tianjin Medical University
- Modality
- Small Molecules, Peptides
- Administration
- Implant, Oral, Subcutaneous
01
Overview
Luminal type-2 is a combination therapeutic regimen evaluated in the Phase 2 STAMP clinical trial for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Developed by the Second Hospital of Tianjin Medical University, the regimen consists of the gonadotropin-releasing hormone (GnRH) agonist goserelin, the CYP17A1 inhibitor abiraterone, and the corticosteroid prednisone. It is specifically administered to patients identified with the luminal molecular subtype of prostate cancer who are randomized to receive this experimental androgen receptor-targeted therapy instead of standard docetaxel chemotherapy.
- Other names
- goserelin + abiraterone + prednisonegoserelin + abiraterone acetate + prednisonegoserelin, abiraterone, and prednisone
02
Targets
CYP17A1 (Steroid 17-alpha-hydroxylase/C17,20 lyase)GR (Glucocorticoid receptor)GnRHR (Gonadotropin-releasing hormone receptor)
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