Drug intelligence / Profile preview

Luobuma

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Luobuma is a traditional Chinese medicinal herb derived from the leaves of *Apocynum venetum* L. It is primarily utilized in East Asia for the management of hypertension, hyperlipidemia, and neurasthenia. The therapeutic effects are attributed to its high concentration of flavonoids, including quercetin, rutin, and hyperoside. Mechanistically, Luobuma exerts antihypertensive effects through vasodilation, potentially mediated by the nitric oxide-cGMP pathway and the inhibition of angiotensin-converting enzyme (ACE). It also exhibits sedative and anxiolytic properties, likely through the modulation of the GABAergic system. Additionally, its antioxidant and diuretic properties contribute to its cardiovascular profile.

Brand names
Luobuma TeaLuobuma Tablets
Other names
Apocynum venetumBluish DogbaneVenetum teaSword-leaf Dogbane
02

Targets

NaV (Voltage-gated sodium channels)ABCB1 (P-glycoprotein)

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