Drug intelligence / Profile preview

lupenone

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Lupenone is a natural lupane-type triterpenoid, a class of organic compounds found in various medicinal plants and fruits. It has demonstrated a wide range of biological activities, including anti-diabetic, anti-cancer, anti-inflammatory, antimalarial, neuroprotective, anti-human papillomavirus (HPV), antibacterial, antioxidant, anti-infertility, and antiviral effects. Research indicates its potential as a therapeutic agent for conditions such as colon cancer, malaria, cisplatin-induced neuropathic pain, HPV-associated cervical cancer, Kawasaki disease, neurodegenerative diseases, diabetic nephropathy, SARS-CoV-2 infection, non-small cell lung carcinoma, and infertility.

02

Targets

RELA (Nuclear Factor Kappa B Subunit p65)IL1B (Interleukin-1 beta)IκBα (NF-kappa-B inhibitor alpha)CCL2 (C-C motif chemokine 2)TNFA (Tumor necrosis factor alpha (soluble))

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