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Luprodex
- Development stage
- Phase 3
- Lead developer
- Bharat Serums and Vaccines
- Modality
- Peptides
- Administration
- Intramuscular, Subcutaneous
01
Overview
Luprodex is a sustained-release depot formulation of leuprolide acetate developed by Bharat Serums & Vaccines. It functions as a gonadotropin-releasing hormone (GnRH) agonist that targets the GnRH receptor in the pituitary gland. Upon initial administration, it causes a transient increase in the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH); however, continuous exposure leads to the downregulation and desensitization of these receptors. This results in a profound reduction in LH and FSH secretion, which in turn suppresses the production of testosterone in males and estrogen in females to castrate or postmenopausal levels. The drug utilizes a biodegradable polymer-based novel drug delivery system (NDDS) to provide controlled release over 1, 3, or 6 months, and is primarily indicated for the treatment of hormone-sensitive conditions such as advanced prostate cancer and endometriosis.
- Brand names
- Luprodex
- Other names
- leuprolide acetate depotleuprolide acetate NDDS
02
Targets
GnRHR (Gonadotropin-releasing hormone receptor)
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