Drug intelligence / Profile preview

lurasidone injectable suspension

Development stage
Unknown
Lead developer
Sumitomo Pharma
Modality
Small Molecules
Administration
Intramuscular
01

Overview

Lurasidone injectable suspension (DSP-1349M) is a long-acting formulation of the atypical antipsychotic lurasidone. It acts as an antagonist at dopamine D2 and serotonin 5-HT2A receptors and has additional activity as a partial agonist at 5-HT1A receptors and antagonist at 5-HT7 and 5-HT2C receptors. Lurasidone is primarily developed for the treatment of schizophrenia but is also used in bipolar depression. The injectable formulation (DSP-1349M) was designed to provide sustained drug delivery for improved adherence in patients with schizophrenia[1][3][5]. The drug was originally developed by Dainippon Sumitomo Pharma (now Sumitomo Pharma), with Sunovion Pharmaceuticals involved in clinical development[1][3].

Other names
lurasidone hydrochloridelurasidone HCllurasidone injection suspension
02

Targets

ADRA2C (α2C)DRD2 (Dopamine D2 Receptor)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)HTR7 (5-hydroxytryptamine receptor 7)

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