Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
luspatercept + thalidomide
- Development stage
- Phase 2
- Lead developer
- Bristol Myers Squibb
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Subcutaneous, Oral
01
Overview
luspatercept + thalidomide is a combination therapy being investigated for the treatment of transfusion-dependent β-thalassemia. Luspatercept is a recombinant fusion protein that acts as an erythroid maturation agent by binding specific TGF-β superfamily ligands (such as GDF11 and activin B), thereby inhibiting SMAD2/3 signaling and promoting late-stage erythropoiesis. Thalidomide is an immunomodulatory small molecule that, in the context of hemoglobinopathies, is used at low doses to induce fetal hemoglobin (HbF) production, potentially through the modulation of the cereblon (CRBN) E3 ubiquitin ligase complex. This combination, currently being evaluated in a Phase 2 trial sponsored by Rongrong Liu, aims to provide a synergistic effect by both enhancing red blood cell maturation and increasing hemoglobin levels to reduce transfusion requirements.
- Other names
- luspatercept-aamt
02
Targets
INHBB (Activin B)BMP6 (Bone morphogenetic protein 6)CRBN (Cereblon)GDF11 (Growth differentiation factor 11)GDF8 (Myostatin)
Beyond the preview
Go deeper on luspatercept + thalidomide.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on luspatercept + thalidomide.