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luteinizing hormone-releasing hormone-conjugated magnetite nanoparticles
- Development stage
- Unknown
- Modality
- Peptide-Drug Conjugates → Peptide Conjugates → Peptides, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Luteinizing hormone-releasing hormone-conjugated magnetite nanoparticles are a targeted nanomedicine platform composed of a magnetite (Fe3O4) nanoparticle core, often coated with polyethylene glycol (PEG), and surface-conjugated to LHRH peptides. The conjugation exploits the overexpression of LHRH receptors on the surfaces of certain cancer cells (notably in breast and lung cancer), enabling active targeting for enhanced delivery of imaging agents or antineoplastic drugs (such as doxorubicin, paclitaxel, or prodigiosin). These nanoparticles allow for magnetic targeting, MRI contrast enhancement, targeted chemotherapy, and hyperthermic therapy. Their mechanism is to increase accumulation at tumor sites while reducing off-target toxicity, by binding to LHRH receptors and facilitating localized drug delivery or hyperthermia under an external magnetic field[2][3][4][5].
- Other names
- LHRH-conjugated magnetite nanoparticlesLHRH-Fe3O4 nanoparticlesLHRH-Fe-3O4 nanoparticlesLHRH-Fe 3O4 nanoparticlesLHRH-tagged PEG-coated magnetite nanoparticlesLHRH-MNPs
02
Targets
GnRHR (Gonadotropin-releasing hormone receptor)
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