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lutetium (177Lu) FAP-75
- Development stage
- Unknown
- Lead developer
- Fudan University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Lutetium (177Lu) FAP-75 is a targeted radiopharmaceutical designed for the treatment of advanced solid tumors. Developed by Fudan University, this agent utilizes the beta-emitting radioisotope Lutetium-177 conjugated to a ligand (FAP-75) that specifically targets Fibroblast Activation Protein (FAP). FAP is highly expressed on cancer-associated fibroblasts within the tumor microenvironment of many solid tumors, while being minimally present in healthy tissues. Upon binding to FAP, the Lutetium-177 delivers localized radiation, inducing DNA damage and subsequent apoptosis in tumor cells, thereby minimizing damage to surrounding healthy tissues.
- Other names
- 镥[177Lu]-FAP-75
02
Targets
FAP (Fibroblast activation protein alpha)
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