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lutetium (177Lu) rosopatamab tetraxetan + docetaxel
- Development stage
- Unknown
- Lead developer
- Telix Pharmaceuticals
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
This is a **combination drug** consisting of **lutetium (177Lu) rosopatamab tetraxetan** and **docetaxel**. Lutetium (177Lu) rosopatamab tetraxetan is a radio-antibody-drug conjugate (rADC) comprised of the therapeutic isotope lutetium-177 attached to the monoclonal antibody rosopatamab, which targets the **prostate-specific membrane antigen (PSMA)** expressed on prostate cancer cells[1][6][8]. When administered, the antibody binds PSMA on tumor cells, delivering local beta radiation that causes DNA damage and tumor cell death while minimizing harm to adjacent healthy tissue[5][6][8]. Docetaxel is a chemotherapy agent that stabilizes microtubules, disrupting cell division. The combination is under investigation for **PSMA-positive metastatic castration-resistant prostate cancer (mCRPC)** after androgen receptor pathway inhibitor therapy[1][3][7]. This therapeutic approach is being evaluated for synergistic efficacy, leveraging both targeted radiotherapy and cytotoxic chemotherapy.
- Other names
- lutetium (177Lu) rosopatamab tetraxetan + docetaxel
02
Targets
DNAPSMA (Prostate-specific membrane antigen)Microtubule
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