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Drug intelligence / Profile preview
lutetium Lu 177 dotatate + lutetium Lu 177 vipivotide tetraxetan
- Development stage
- Unknown
- Lead developer
- Advanced Accelerator Applications
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta-minus Emitters → Radiopharmaceuticals, Gamma Emitters → Radiopharmaceuticals, Peptide-Drug Conjugates → Peptide Conjugates → Peptides, Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
This is a combination of two radiopharmaceutical cancer therapies, each containing the radioactive isotope lutetium-177 but conjugated to different targeting molecules. **Lutathera** (lutetium Lu 177 dotatate) is a peptide receptor radionuclide therapy (PRRT) that targets somatostatin receptors on gastroenteropancreatic neuroendocrine tumors (GEP-NETs). It binds to somatostatin receptor-positive tumor cells and delivers targeted radiation, leading to cell death[2][7]. **Pluvicto** (lutetium Lu 177 vipivotide tetraxetan) is a radioligand therapy that targets prostate-specific membrane antigen (PSMA), which is highly expressed on metastatic castration-resistant prostate cancer cells. By binding PSMA, it delivers localized radiation to these cancer cells[3][4][5][8]. Both drugs are administered intravenously in cycles and are approved for their respective indications.
- Other names
- lutetium Lu 177 dotatate + lutetium Lu 177 vipivotide tetraxetan
02
Targets
PSMA (Prostate-specific membrane antigen)SSTR2 (Somatostatin receptor type 2)
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