Drug intelligence / Profile preview

luveltamab tazevibulin

Development stage
Phase 2
Lead developer
Sutro Biopharma
Modality
Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

Luveltamab tazevibulin is a novel homogeneous folate receptor alpha (FolRα) targeting antibody-drug conjugate (ADC). It uses a stable cleavable linker and a 3-aminophenyl hemiasterlin warhead to induce cytotoxic and immunologic cell death. Developed by Sutro Biopharma, it is primarily investigated for the treatment of ovarian cancer, particularly in patients with platinum-resistant disease. It has also been granted an orphan designation for the treatment of pediatric acute myeloid leukemia.

Brand names
luvelta
Other names
luveltamab tazevibulinSTRO-002STRO002STRO 002
02

Targets

FOLR1 (FRα)

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