Drug intelligence / Profile preview

LV009

Development stage
Phase 1
Lead developer
PersonGen BioTherapeutics
Modality
CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
Administration
Intravenous
01

Overview

**LV009** is an investigational in vivo CAR-T cell therapy product developed as an injectable formulation (LV009注射液) that delivers CD19-targeted CAR genes directly into patients to generate CAR-T cells internally, targeting CD19-positive hematologic malignancies. It represents a novel approach to CAR-T therapy by leveraging lentiviral vector-based gene delivery to reprogram T cells without the need for ex vivo cell manipulation, potentially simplifying manufacturing and administration. Primarily indicated for relapsed/refractory CD19-positive blood and lymphatic system malignancies, such as B-cell lymphomas and leukemias, with ongoing evaluation of safety and efficacy in early clinical trials conducted in China.[5][8][9]

Other names
CD19 CAR-T cellsCD-19 CAR-T cellsCD 19 CAR-T cellsanti-CD19 CAR-T cellsanti-CD-19 CAR-T cellsanti-CD 19 CAR-T cells
02

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