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LVIVO-TaVec400

Development stage: Phase 1
Lead developer: Institute of Hematology and Blood Diseases Hospital
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
Administration: Intravenous

Overview

LVIVO-TaVec400 is an investigational *in vivo* chimeric antigen receptor (CAR) T-cell therapy being developed by the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences. Unlike traditional CAR-T therapies that require complex *ex vivo* manufacturing (collecting, modifying, and re-infusing cells), LVIVO-TaVec400 utilizes a lentiviral vector system (the TaVec platform) to genetically engineer T cells directly within the patient's body. The vector is designed to deliver a gene encoding a CAR that targets B-cell maturation antigen (BCMA), a protein highly expressed on malignant plasma cells. This approach aims to simplify the treatment process and reduce the time to therapy for patients with relapsed or refractory multiple myeloma.

Other names: LVIVO-TaVec400 productLVIVO-TaVec-400 productLVIVO-TaVec 400 product

Targets

BCMA (B-cell maturation antigen)

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