LY2817412

LY2817412 is a potent, selective, and orally active antagonist of the nociceptin/orphanin FQ (NOP) receptor. It exhibits high affinity for the recombinant human NOP receptor (Ki ≈ 0.18 nM) and has been shown in preclinical studies to dose-dependently and selectively reduce voluntary alcohol and nicotine intake, as well as cue- and yohimbine-induced reinstatement of alcohol-seeking and nicotine-seeking behaviors in animal models. LY2817412 is utilized primarily as an experimental research tool to probe the role of NOP receptor antagonism in addiction-related behaviors, and has been investigated for potential therapeutic application in the treatment of alcohol use disorder and nicotine dependence.[1][2][3][5][7][9][10]

Other names

LY2817412LY-2817412LY 2817412