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LY3200327 is a monoclonal antibody developed by Eli Lilly for the inhibition of interleukin-21 (IL-21). It was investigated primarily as an IL-21 inhibitor for immune system diseases, including systemic lupus erythematosus (SLE). The drug acts as an antagonist to IL-21 and was studied in early-phase clinical trials to evaluate its safety, tolerability, and pharmacokinetics. Development has since been discontinued.
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