Drug intelligence / Profile preview

LY3316531

Development stage
Phase 1
Lead developer
Eli Lilly
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Subcutaneous, Intravenous
01

Overview

LY3316531 is an investigational monoclonal antibody developed by Eli Lilly for the treatment of psoriasis. It has been studied in both healthy participants and patients with psoriasis, administered via subcutaneous or intravenous routes. The drug’s primary mechanism of action is believed to be the neutralization of calcitonin gene-related peptide (CGRP), as evidenced by clinical trial protocols assessing its effect on capsaicin-induced dermal blood flow—a process mediated by CGRP. The molecule is classified as a new molecular entity and falls under the antipsoriatic class, though its precise mechanism remains officially undefined in public sources[2][5][7]. Clinical development appears to have reached Phase 1, with no recent reports indicating further advancement[2][3].

Other names
LY 3316531LY3316531LY-3316531
02

Targets

CGRP (Calcitonin gene-related peptide)

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