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LY3509754

Development stage: Discontinued
Lead developer: Eli Lilly
Modality: Small Molecules
Administration: Oral

Overview

LY3509754 is an oral small molecule inhibitor of interleukin-17A (IL-17A) developed by Eli Lilly for the treatment of psoriasis and other immune-mediated disorders. It demonstrated strong target engagement and a pharmacokinetic profile supporting once-daily administration, with a time to maximum concentration of 1.5-3.5 hours and terminal half-life of 11.4-19.1 hours. Despite promising pharmacokinetics, development was discontinued due to drug-induced liver injury observed in clinical trials.

Other names: IL-17 A small molecule inhibitor - Eli LillyIL17 A small molecule inhibitor - Eli LillyIL 17 A small molecule inhibitor - Eli LillyInterleukin-17A small molecule inhibitor - Eli LillyInterleukin17A small molecule inhibitor - Eli LillyInterleukin 17A small molecule inhibitor - Eli Lilly

Targets

IL-17A (Interleukin-17A)

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