LY379268

**LY379268** is a potent, highly selective **agonist** for group II metabotropic glutamate receptors (**mGluR2/3**). It is a small synthetic molecule used primarily in neuroscience research to study the function of these glutamate receptors. By activating mGluR2/3, LY379268 reduces excessive glutamate release, which is implicated in various neurodegenerative and psychiatric disorders. Preclinical studies indicate its potential in animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain. It has demonstrated neuroprotective effects, modulation of anxiety-like behavior, and attenuation of drug-seeking behaviors such as cocaine and methamphetamine self-administration. LY379268 is not approved for clinical use and is mainly a research tool compound[3][5][7][10].

Other names

(1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid(−)-2-oxa-4-aminobicyclohexane-4,6-dicarboxylic acidLY 379268 disodium saltLY379268 disodium saltLY-379268 disodium salt