Drug intelligence / Profile preview

LY4170156 + bevacizumab

Development stage
Unknown
Lead developer
Eli Lilly
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

LY4170156 + bevacizumab is a combination investigational regimen being studied for advanced solid tumors in a multi-part Phase 1 trial. LY4170156 is an experimental agent (molecular class and precise target undisclosed in available sources) developed by Eli Lilly and Company, while bevacizumab is an approved monoclonal antibody that inhibits vascular endothelial growth factor A (VEGF-A), thereby blocking angiogenesis. This combination is administered intravenously and aims to evaluate safety, tolerability, and preliminary anti-tumor activity, including progression free survival, overall response rate, and other clinical endpoints in ovarian, endometrial, colorectal, cervical, pancreatic, non-small cell lung, and triple-negative breast cancers[1][2][4].

Other names
LY4170156 + bevacizumab
02

Targets

TOP1 (DNA Topoisomerase I)VEGFA (Vascular endothelial growth factor A)FOLR1 (FRα)

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