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lycorine hydrochloride thioester
- Development stage
- Unknown
- Lead developer
- Shandong Dain Marine Biopharmaceutical
- Modality
- Small Molecules
- Administration
- Injection
01
Overview
Lycorine hydrochloride thioester is a small molecule derivative of the natural alkaloid lycorine, specifically modified as a thioester hydrochloride salt to enhance its pharmacological profile. Developed by Shandong Dain Marine Biopharmaceutical, it is being investigated as a treatment for hand, foot and mouth disease (HFMD), which is primarily caused by Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16). The compound exerts its antiviral effect by inhibiting viral replication; research suggests it interferes with viral RNA synthesis and protein translation, possibly through the inhibition of the viral 3C protease or RNA-dependent RNA polymerase. The drug has advanced into early clinical trials in China, representing a novel therapeutic approach for a disease that currently lacks specific antiviral treatments.
- Other names
- lycorine thioester hydrochloridelycorine hydrochloride thioester derivative
02
Targets
3Cpro (Enterovirus 3C protease)RdRp (Coronavirus RNA-dependent RNA polymerase)
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