lymphocyte infusions

Lymphocyte infusions developed by St. Jude Children's Research Hospital refer to an investigational cellular therapy used in the context of hematopoietic cell transplantation (HCT) for pediatric and young adult patients with high-risk hematological malignancies. This specific protocol involves the collection of peripheral blood stem cells (PBSC) from a haploidentical donor following mobilization with G-CSF. The collected cells are processed using the CliniMACS Cell Selection System and CD34 Microbead reagents to achieve T-cell depletion or specific cell isolation (such as CD3+ T cells). The resulting product is infused into the patient to facilitate donor engraftment and provide a graft-versus-leukemia (GVL) effect, which helps prevent disease relapse while minimizing the risk of severe graft-versus-host disease (GVHD). This approach is often evaluated as part of a complex preparative regimen involving total lymphoid irradiation (TLI) and umbilical cord blood transplantation.

Other names

donor lymphocyte infusionDLIT-cell depleted haploidentical peripheral blood stem cellsTCD-PBSC