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lyophilized allogeneic fecal microbiota
- Development stage
- Unknown
- Lead developer
- Amsterdam UMC
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lyophilized allogeneic fecal microbiota is an investigational microbiome-based therapeutic developed by Amsterdam UMC. It consists of pooled donor fecal microbiota that has been freeze-dried (lyophilized) and encapsulated for oral administration. The product aims to modulate the gut microbiome, restore microbial diversity, and reduce systemic inflammation. It is currently being evaluated in the CACHEXIS clinical trial as an adjunctive therapy to standard chemotherapy (paclitaxel and ramucirumab) for patients with advanced gastroesophageal cancer and cancer cachexia, with the goal of improving nutritional status and treatment response.
- Other names
- lyophilized pooled allogeneic fecal microbiotaFMT capsulesfecal microbiota transplantation capsules
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