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Lyophilized allogeneic fecal microbiota is an investigational microbiome-based therapeutic developed by Amsterdam UMC. It consists of pooled donor fecal microbiota that has been freeze-dried (lyophilized) and encapsulated for oral administration. The product aims to modulate the gut microbiome, restore microbial diversity, and reduce systemic inflammation. It is currently being evaluated in the CACHEXIS clinical trial as an adjunctive therapy to standard chemotherapy (paclitaxel and ramucirumab) for patients with advanced gastroesophageal cancer and cancer cachexia, with the goal of improving nutritional status and treatment response.
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