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Lyophilized Fecal Microbiota Transplantation (Island Health)
- Development stage
- Unknown
- Lead developer
- Island Health
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lyophilized Fecal Microbiota Transplantation (L-FMT) is an investigational live biotherapeutic product developed by the Vancouver Island Health Authority (Island Health). [3, 5] It is a freeze-dried, powdered formulation of fecal microbiota sourced from healthy donors, designed for oral administration in capsules. [1, 3, 4] L-FMT is intended to treat recurrent *Clostridioides difficile* infection (CDI) by restoring a healthy and diverse gut microbiome. [1, 2] The introduction of a healthy microbial community helps to competitively exclude the pathogenic *C. difficile* bacteria, resolving the infection and preventing relapse. [7] The lyophilized format offers advantages over fresh or frozen preparations, including prolonged shelf life at standard refrigerator temperatures, ease of storage and shipping, and a more convenient administration method. [1, 3, 7]
- Other names
- Lyophilized Fecal Microbiota Transplantation-Vancouver Island Health Authority-Clostridioides difficile infection
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