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Lyophilized Microbiota
- Development stage
- Unknown
- Lead developer
- University of Texas Health Science Center at Houston
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lyophilized Microbiota is an investigational live biotherapeutic product developed by The University of Texas Health Science Center at Houston (UTHealth Houston) for the treatment of recurrent *Clostridioides difficile* infection (CDI). The therapy consists of a complex community of intestinal bacteria derived from screened healthy donors, which is filtered and freeze-dried (lyophilized) to create a stable, encapsulated inoculum. Administered orally, the product is designed to restore microbial diversity and functional balance within the gut microbiome. By re-establishing colonization resistance, the transplanted microbiota outcompetes *C. difficile* pathogens and restores normal bile acid metabolism, thereby preventing further recurrences of the infection. It has been evaluated in Phase 1/2 clinical trials comparing its safety and efficacy to frozen microbiota delivered via retention enema.
- Other names
- Lyophilized donor intestinal bacteriaLyophilized fecal microbiota transplantationLyophilized FMTLyophilized Microbiota
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