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lyophilized platelet-rich fibrin
- Development stage
- Phase 1
- Administration
- Topical, Implantation
01
Overview
Lyophilized platelet-rich fibrin (Ly-PRF) is a stabilized, freeze-dried formulation of second-generation platelet concentrate derived from autologous blood. Unlike fresh platelet-rich fibrin (PRF), which must be used immediately, the lyophilization process preserves the dense three-dimensional fibrin network and stabilizes bioactive growth factors, extending the product's shelf life and allowing for easier clinical handling. Ly-PRF acts as a bioactive scaffold and reservoir for essential growth factors, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and transforming growth factor-beta (TGF-β). It is primarily used in regenerative medicine and tissue engineering to promote bone regeneration, angiogenesis, and wound healing by providing a sustained release of these factors, which in turn stimulates the proliferation and osteogenic differentiation of mesenchymal stem cells.
- Other names
- freeze-dried platelet-rich fibrinlyophilized PRFL-Platelet-rich fibrin
02
Targets
IGF-1 (Insulin-like growth factor 1)PDGF (Platelet-derived Growth Factor family)VEGFA (Vascular endothelial growth factor A)BMP2 (Bone morphogenetic protein 2)TGFB (GARP–latent transforming growth factor beta 1 complex)
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