Drug intelligence / Profile preview

Lysergide

Development stage
Phase 2
Lead developer
Definium Therapeutics
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Sublingual, Intravenous, Intramuscular, Transdermal
01

Overview

Lysergide, also known as lysergic acid diethylamide (LSD), is a semi-synthetic hallucinogen and one of the most potent psychoactive substances known. It was first synthesized in 1938 by Albert Hofmann at Sandoz Laboratories. Lysergide is an ergoline alkaloid derived from lysergic acid, which itself is produced from ergot alkaloids found in the fungus Claviceps purpurea. The drug acts primarily as an agonist at serotonin receptors, especially 5HT2A and 5HT2C, but also activates other serotonin receptor subtypes (including 5HT1A, 5HT1B, 5HT1D, 5HT5A, 5HT6 and 5HT7), as well as dopamine and norepinephrine receptors. Its hallucinogenic effects are mainly attributed to its action on the serotonin system. Lysergide was marketed under the brand name Delysid for psychiatric research and therapeutic purposes during the mid-twentieth century but is now internationally controlled due to its high potential for abuse[1][2][3][4][5][6].

Brand names
Delysid
Other names
lysergic acid diethylamideLSDd-LSDDelysid
02

Targets

HTR2A (Serotonin receptor 5-HT2A)HTR1D (5-hydroxytryptamine receptor 1D)HTR1B (5-Hydroxytryptamine Receptor 1B)HTR7 (5-hydroxytryptamine receptor 7)HTR2C (5-hydroxytryptamine 2C receptor)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

Beyond the preview

Go deeper on Lysergide.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on Lysergide.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call