Drug intelligence / Profile preview

Lysimachia christinae extract

Development stage
Unknown
Lead developer
BASF
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Lysimachia christinae extract is a botanical extract derived from the whole herb of *Lysimachia christinae* Hance (commonly known as Jin Qian Cao or Gold Coin Grass), a traditional Chinese medicinal plant. It is widely utilized in traditional medicine and dietary supplements for its diuretic, litholytic, and hepatoprotective properties, particularly in the treatment of urolithiasis (kidney stones) and gallbladder stones. Beyond its traditional applications, the extract is being investigated for its potential therapeutic benefits in metabolic dysfunction-associated steatotic liver disease (MASLD) and neurodegenerative conditions such as Alzheimer's disease. Mechanistically, the extract exhibits inhibitory activity against acetylcholinesterase (AChE) and aldose reductase, and modulates peroxisome proliferator-activated receptor alpha (PPARA) signaling and downstream inflammatory pathways, including the downregulation of C-X-C motif chemokine 10 (CXCL10). It is also marketed as a cosmetic active ingredient under the brand name Oximony by BASF for skin longevity and anti-senescence applications.

Brand names
Oximony
Other names
Christina Loosestrife extractGold Coin Grass extractHerba Lysimachiae extractJin Qian Cao extractLysimachia christinae Hance extractyellow loosestrife extract
02

Targets

AcetylcholinesteraseAR (Adrenergic receptors)PPARA (Peroxisome proliferator-activated receptor alpha)

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