lysine acetate

Lysine acetate is a salt composed of the essential amino acid L-lysine and acetic acid. While traditionally used as a component of parenteral amino acid solutions for nutritional support, it is being investigated by CHU Gabriel-Montpied as a therapeutic intervention for metabolic acidosis in patients with chronic kidney disease (CKD). The mechanism of action relies on the metabolic conversion of the acetate moiety into bicarbonate, which serves as a systemic buffer to neutralize acid accumulation. This approach offers a significant advantage over standard sodium bicarbonate therapy by providing an alkali source without the associated sodium load, which is critical for CKD patients who often require strict sodium restriction to manage hypertension and fluid retention.

Other names

L-lysine acetatelysine monoacetate