lysine acetylsalicylate + glycine

Lysine acetylsalicylate + glycine is a pharmaceutical combination consisting of the lysine salt of aspirin (acetylsalicylic acid) and the amino acid glycine. Lysine acetylsalicylate is a highly water-soluble prodrug of aspirin, which allows for rapid systemic absorption and the potential for parenteral or inhaled administration. Aspirin acts as an irreversible inhibitor of cyclooxygenase enzymes (COX-1 and COX-2), thereby blocking the synthesis of prostaglandins and thromboxanes, which are key mediators of pain, inflammation, and platelet aggregation. Glycine is included in the formulation primarily as a buffering agent to improve gastric tolerance and reduce mucosal irritation. This combination is widely used for the acute treatment of migraine attacks, moderate-to-severe pain, and fever. Aspiair GmbH has specifically developed an inhaled dry-powder formulation (AS-001) of lysine acetylsalicylate to provide rapid relief for migraine patients, bypassing the gastrointestinal tract and avoiding the delays in absorption often caused by migraine-associated gastric stasis.

Brand names

VenaspirinLabatest

Other names

DL-lysine acetylsalicylate + glycineAspirin lysine + glycineLAS + glycine