Drug intelligence / Profile preview

lysiphyllum strychnifolium

Development stage: Preclinical
Lead developer: Chulabhorn International College of Medicine
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

*Lysiphyllum strychnifolium* (also known as *Bauhinia strychnifolia* or Ya-nang-daeng) is a Thai traditional herbal medicine being investigated for its potential anti-tumor properties, particularly in colorectal cancer (CRC). Research, including proteomic profiling in human colon carcinoma xenograft models, suggests that extracts from this plant may influence cellular pathways related to homeostasis, morphogenesis, and cell membrane components. It is traditionally used in Thailand for its detoxifying and anti-inflammatory effects. Recent studies presented at the ESMO Congress 2025 have explored its efficacy both as a monotherapy and in combination with Vitamin D3, identifying differentially expressed proteins in the serum and spleen of treated models that implicate its role in modulating cellular structural components and metabolic homeostasis.

Other names: Bauhinia strychnifoliaYa-nang-daeng

Targets

ESR1 (ERα)Cyp (Cyclophilin family)SLC5A1 (Sodium Glucose Cotransporter 1)SLC2A2 (Solute carrier family 2 facilitated glucose transporter member 2)

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