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LZ901

Development stage: Phase 3
Lead developer: Beijing Luzhu Biotechnology
Modality: Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration: Intramuscular

Overview

LZ901 is a recombinant herpes zoster vaccine featuring a unique tetrameric molecular structure. It consists of a tetramer of varicella zoster virus (VZV) glycoprotein E (gE) and a human IgG1 Fc fusion protein expressed in CHO cells and adsorbed with aluminum hydroxide adjuvant. The fusion protein is formed by an extracellular domain of the recombinant glycoprotein gE of a live attenuated VZV strain (Oka) and an Fc fragment of human immunoglobulin. Unlike live attenuated virus vaccines, this recombinant protein vaccine induces an immune response while avoiding risks of residual virulence. It requires two injections per treatment without needing a third booster shot.

Targets

gE (VZV glycoprotein E)

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