müllerian inhibiting substance

**Müllerian inhibiting substance (MIS)**, also known as **anti-Müllerian hormone (AMH)**, is a glycoprotein hormone belonging to the **transforming growth factor-β (TGF-β) superfamily**. Produced by immature Sertoli cells in male embryos, it binds to specific type I and type II receptors (serine-threonine kinases) on Müllerian ducts, inducing regression of female reproductive structures including precursors to the fallopian tubes, uterus, cervix, and upper vagina. In adults, MIS/AMH inhibits proliferation of gynecologic tumors (e.g., ovarian, endometrial, cervical cancers) and other cancers expressing its receptors via receptor-mediated cell cycle arrest, apoptosis, and autophagy; preclinical studies show growth inhibition in vitro and in vivo, synergy with chemotherapeutics like paclitaxel and cisplatin, and potential as a non-toxic adjuvant therapy. It also regulates gonadal steroidogenesis (inhibits testosterone via CYP17 suppression), follicle activation for contraception/fertility preservation, and has clinical utility in serum assays for reproductive disorders and tumors.[1][2][5][9]

Other names

anti-müllerian hormoneAMHMIS