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M-CSF shRNA lentivirus
- Development stage
- Preclinical
- Lead developer
- Hallym University
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies
- Administration
- Intralesional
01
Overview
M-CSF shRNA lentivirus is a research-grade gene silencing tool consisting of a lentiviral vector encoding short hairpin RNA (shRNA) designed to knock down the expression of macrophage colony-stimulating factor (M-CSF, also known as CSF1). In preclinical models of mammary cancer, transduction of tumor cells with this lentivirus inhibits M-CSF expression, leading to a reduction in M2 macrophage infiltration, tumor growth, and lung metastasis. It is primarily utilized as a laboratory research reagent to study the crosstalk between cancer cells and tumor-associated macrophages in the tumor microenvironment.
- Other names
- M-CSF shRNA Lentiviral Particlesmacrophage colony-stimulating factor short hairpin RNA lentivirus
02
Targets
Colony stimulating factor 1 messenger RNACSF1R (Macrophage colony-stimulating factor receptor)
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