M-DM1

**M-DM1** is an experimental melittin-derived peptide-drug conjugate comprising melittin, a 26-amino-acid bee-venom peptide used as an M2-like tumor-associated macrophage-targeting carrier, covalently linked to the maytansinoid microtubule inhibitor mertansine. It was evaluated preclinically in melanoma models, where it preferentially induced apoptosis in M2-like tumor-associated macrophages, reduced immunosuppressive macrophage infiltration, increased intratumoral CD8-positive T-cell and natural-killer-cell infiltration, and inhibited B16-F10 melanoma growth. The reported evidence is limited to in-vitro and mouse-model research; no clinical development or approved use has been identified. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC10140360/))

Other names

melittin-DM1 conjugatemelittin-DM-1 conjugatemelittin-DM 1 conjugatemelittin-mertansine conjugate