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M-T7
- Development stage
- Preclinical
- Lead developer
- Viron Therapeutics
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Subdural, Systemic
01
Overview
M-T7 is a secreted myxoma viral immunomodulatory glycoprotein that acts as a potent anti-inflammatory agent. It exhibits dual functions: inhibiting rabbit IFN-γ by mimicking its receptor and acting as a chemokine-binding protein. This chemokine-binding activity is species-nonspecific, allowing it to interact with a wide range of C, C-C, and C-X-C chemokines. Through these mechanisms, M-T7 has demonstrated efficacy in preclinical models by reducing intimal hyperplasia and inflammatory cell invasion after vascular injury, and by attenuating early inflammation following spinal cord injury.
- Other names
- viral anti-inflammatory chemokine-binding protein M-T7myxoma viral protein M-T7poxvirus-derived secreted immunomodulatory protein M-T7viral chemokine modulating protein M-T7
02
Targets
IFNG (Interferon gamma)Chemokine–glycosaminoglycan interaction
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