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M5 PH1 ADC
- Development stage
- Preclinical
- Lead developer
- Peak Bio
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
M5 PH1 ADC is a preclinical antibody-drug conjugate (ADC) being developed by Peak Bio (formerly Peak Computing) for the treatment of solid tumors. It is part of the company's TORPEDO™ (Targeted RNA-splicing Or Potent Effector Delivery Optimization) platform. The drug utilizes a novel toxin payload (potentially designated PH1 or related to the PH-5/PH-6 programs) designed to target and disrupt the RNA splicing machinery within cancer cells. While the specific molecular target of the antibody component has not been publicly disclosed, the TORPEDO™ platform aims to improve the therapeutic index of ADCs by using proprietary toxins that interfere with splicing, a mechanism distinct from traditional microtubule inhibitors or DNA-damaging agents.
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