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m8Δ + AAV-Pv(s25-CSP)
- Development stage
- Preclinical
- Lead developer
- Kanazawa University
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intradermal, Intramuscular
01
Overview
m8Δ + AAV-Pv(s25-CSP) is a preclinical-stage, heterologous viral-vectored multistage vaccine candidate developed for the prevention of Plasmodium vivax malaria. The vaccine platform utilizes a prime-boost regimen consisting of a highly attenuated vaccinia virus strain, LC16m8Δ (m8Δ), as the prime, followed by a recombinant adeno-associated virus (AAV) boost. The vectors harbor a fusion gene encoding the pre-erythrocytic stage antigen Plasmodium vivax circumsporozoite protein (PvCSP) and the sexual stage antigen Pvs25. This dual-antigen approach is designed to elicit robust antibody responses that provide both sterile protection against sporozoite challenge and transmission-blocking efficacy to prevent the spread of the parasite.
- Other names
- m8Δ/AAV-Pv(s25-CSP)m8Δ/AAV1-Pv(s25-CSP)m8Δ/AAV1-Pv(s25-CSP-VK210/247)
02
Targets
Pvs25 (Plasmodium vivax ookinete surface protein 25)CSP (Circumsporozoite protein)
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