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Ma Ren Wan is a traditional Chinese medicine (TCM) herbal formula used primarily for the treatment of constipation due to intestinal dryness and heat. The classic formulation consists of six main herbs: Huo Ma Ren (Fructus Cannabis), Da Huang (Radix et Rhizoma Rhei), Bai Shao (Radix Paeoniae Alba), Xing Ren (Semen Armeniacae Amarum), Zhi Shi (Fructus Aurantii Immaturus), and Hou Pu (Cortex Magnoliae Officinalis). The mechanism of action is thought to involve moistening the intestines, softening stool, reducing water absorption in the colon, activating intestinal mucosa, and promoting gastrointestinal motility. It is widely used in China for functional constipation—especially among elderly patients—and has also been studied for use in cancer patients with chemotherapy- or opioid-induced constipation. Adverse effects are generally mild but may include abdominal pain, cramping, bloating, diarrhea, gas, nausea or vomiting[2][3][4].
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