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MAAT Evolute
- Development stage
- Unknown
- Lead developer
- Mati Therapeutics
- Modality
- Small Molecules, Implantable Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Ophthalmic
01
Overview
MAAT Evolute is a sustained-release ocular drug delivery system developed by Mati Therapeutics for the treatment of glaucoma and ocular hypertension. The system utilizes a proprietary L-shaped punctal plug inserted into the tear duct (punctum) to provide continuous medication delivery to the tear film. The device consists of a drug-eluting core, typically containing the prostaglandin analog travoprost, encapsulated in a polymer sleeve with a cyanoacrylate film to ensure unidirectional release. This platform technology aims to address patient compliance issues associated with traditional daily eye drop therapies by providing continuous drug delivery through a simple office-based procedure. Clinical trials have demonstrated high retention rates and significant reduction in intraocular pressure over extended periods.
- Brand names
- MAAT Evolute
- Other names
- EvoluteEvolute Punctal PlugMati Punctal Plug Drug Delivery System
02
Targets
PTGFR (Prostaglandin F2 alpha receptor)
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